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ASH 2024 preview – more challenges to the BTK order

First-gen drugs feature in BCL-2 combos, while Jaypirca and BTK degraders apply extra pressure.

Regeneron keeps up its co-stimulatory crusade

The company’s CD38 x CD28 MAb is among recent clinical trial entrants.

Heartache for Syndax

Response rates in relapsed NPM1-mutant AML look slightly worse than before, but QTc prolongation could be the real worry.

ASH 2024 preview – multiple myeloma in focus

AbbVie looks to justify its faith in TeneoOne, and Bristol its phase 3 move with BMS-986393.

The morning after ProfoundBio

Genmab quietly reveals pipeline discontinuations and a delay to the son of Darzalex.

ASH 2024 preview – CD19 back on the agenda

Astra squares up to Merck's Curon deal, while Novartis and Galapagos face off in fast-manufactured Car-T.

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