First-in-human listings bring a bispecific and yet another in vivo Car-T.
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But the Astra/Daiichi ADC stumbles in lung cancer.
Relapsed data are uncompetitive, but the front-line PACC-mutant space offers hope.
The company’s AN9025 will shortly enter phase 1.
The upcoming Rasolute-304 trial will compare daraxonrasib versus observation.
With a phase 3 trial of the trispecific T-cell engager ramantamig, J&J will challenge itself.
Though lung cancer looks promising a partner is now needed.
Deteriorating efficacy and a treatment-related death with Zynlonta plus Columvi spook investors.
