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Heartache for Syndax

Response rates in relapsed NPM1-mutant AML look slightly worse than before, but QTc prolongation could be the real worry.

ASH 2024 preview – multiple myeloma in focus

AbbVie looks to justify its faith in TeneoOne, and Bristol its phase 3 move with BMS-986393.

ASH 2024 preview – menin inhibitors face off again

Kura will see more combo data, while a new contender from Sumitomo emerges.

The morning after ProfoundBio

Genmab quietly reveals pipeline discontinuations and a delay to the son of Darzalex.

ASH 2024 preview – CD19 back on the agenda

Astra squares up to Merck's Curon deal, while Novartis and Galapagos face off in fast-manufactured Car-T.

Next for Trodelvy: small-cell lung cancer

Second-line NSCLC is a $1.8bn write-off, and Gilead plans phase 3 in SCLC.