Two cast-offs comprise the private group's attempts to hit PARP1 and PARP7.

Selectively hitting PARP1 is meant to reduce toxicity, and arguably the Petra trial shows this.

AstraZeneca and Lilly put PARP1 and KRAS G12C inhibitors into their first phase 3s, while Amgen advances DLL3 into early-stage disease.

But today’s deal with Jiangsu Hengrui doesn’t mean that the group is turning away from an earlier tie-up with Nerviano.