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  1. Pfizer shuffles its deck post-Seagen

    … Beijing Immunochina Early China ph1 ; data at ESMO 2023: ORR 11% in 9 pts GCC19CART Car-T …

    - 02/01/2024 - 14:51

  2. Roche walks away from Hookipa’s KRAS immunotherapy

    … immunotherapy HPV16+ HNSCC Ph1/2 1L + Keytruda ESMO 2023: 42% ORR (8/19 pts); more data due H1 2024; …

    - 01/30/2024 - 13:42

  3. Trodelvy throws second-line lung cancer another curveball

    … and a secondary endpoint in Evoke-01. Source: ESMO 2023 & Gilead press release. Trial …

    - 01/23/2024 - 15:04

  4. ASCO-GI – Jacobio’s KRAS looks competitive in pancreatic

    … cancer with its multi-RAS inhibitor RMC-6236 at ESMO 2023; however, this study excluded G12C mutants. …

    - 01/18/2024 - 14:56

  5. ASCO-GU preview: showdown for Exelixis

    … in neuroendocrine prostate cancer 121 Had data at ESMO 2023; company sold to Merck & Co Keynote-564 …

    - 01/25/2024 - 10:22

  6. Cell cycle niche seeks clinical validation

    … +/- platinum chemo, started Aug 2023; preclinical data at ESMO 2023 AZD8421 AstraZeneca Cycad-1 trial …

    - 01/12/2024 - 17:23

  7. J&J deal cements Ambrx’s transformation

    … cohorts 4-8 the confirmed ORR was 22%.   Source: ESMO 2023.   Any lingering doubts now become …

    - 01/10/2024 - 14:31

  8. Merck’s latest move is in bispecifics

    … toxicity.  In a phase 1/2 study presented at ESMO 2023 HPN328 produced a confirmed response rate of 32% … house Ph1 +/- Keytruda in solid tumours ; data at ESMO 2023 Not yet given Source: Mizuho note, …

    - 06/19/2024 - 16:48

  9. ASCO-GI preview: notable late-breakers

    … 604 KRAS G12C inhibitor with solid tumour data at ESMO 2023 Defiance Leap Therapeutics DKN-01 + …

    - 01/09/2024 - 11:43

  10. Merck KGaA takes a punt on Inspirna’s novel approach

    … with ompenaclid in second-line CRC Source: ESMO 2023.   By way of benchmarks, Folfiri chemo …

    - 01/05/2024 - 13:36