Leap-012 delivers a technical win, but filing might hinge on overall survival and a call on toxicity.

Relativity-104 is revealed as a failure, and the phase 3 it just spawned could fail too.

But the Galaxies Lung-201 trial features notable omissions, plus toxicity.

Efficacy with the group’s next-gen ALK and ROS1 inhibitors holds up, and first-line use could beckon.

The group’s B7-H3 ADC looks competitive versus rival projects from Merck/Daiichi and GSK/Hansoh.

The company’s HIF-2α inhibitor impresses on efficacy, but its long half life raises eyebrows.

Prelude’s SMARCA2 project and C4’s BRAF hopeful look lacklustre.

Backed by a slender survival signal the industry’s only anti-fucosyl-GM1 MAb is to go pivotal.