Other new first-in-human trials involve CD74, where Gilead and Sutro tried and failed, and the emerging target MAT2A.

Bicara and DualityBio will soon test market appetite for new oncology issues.

Belrestotug’s lung cancer trial features among the ESMO late-breakers, as do Immutep, Scorpion and others.

The leading proponents of selective SMARCA2 inhibition are taking their oral projects into clinical trials.

Second time lucky for Zynyz, Amgen’s PRMT5 comeback, and other possible surprises.

Dizal and Daiichi have set the bar, but a lack of other interest in ITK inhibition could ring alarm bells.

Meanwhile, recent updates hint at more issues in the group’s pipeline of bispecific MAbs.