What Relay managed with a combo Scorpion might be able to do with STX-478 monotherapy.
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Despite seeing dose-limiting toxicities, the group is going higher with its KRAS G12D project.
Having failed to get Zynyz approved in the second-line setting the group has the front line in its sights.
The company’s HIF-2α inhibitor impresses on efficacy, but its long half life raises eyebrows.
The group’s B7-H3 ADC looks competitive versus rival projects from Merck/Daiichi and GSK/Hansoh.
Efficacy with the group’s next-gen ALK and ROS1 inhibitors holds up, and first-line use could beckon.
But the Galaxies Lung-201 trial features notable omissions, plus toxicity.
Relativity-104 is revealed as a failure, and the phase 3 it just spawned could fail too.
